πŸ§ͺ Medication Checker

Check drug interactions and contraindications with ibogaine treatment

Medically reviewed: March 2026By: Dr. Elena Vasquez, PharmD, PhD(Clinical Pharmacology)Editorial policy

⚠️ Important Disclaimer

This tool provides general guidance only. Always consult with your ibogaine clinic's medical team about your specific medications. Some drugs require professional tapering protocols.

🚫 MUST STOP Before Treatment

SSRIs (Prozac, Zoloft, Lexapro, Paxil, Celexa)

Stop: 2-4 weeks before

Risk: Serotonin syndrome

SNRIs (Effexor, Cymbalta, Pristiq)

Stop: 2-4 weeks before

Risk: Serotonin syndrome

MAO Inhibitors (Selegiline, Rasagiline, Phenelzine)

Stop: 2-3 weeks before

Risk: Hypertensive crisis, serotonin syndrome

Tricyclic Antidepressants (Amitriptyline, Nortriptyline)

Stop: 2 weeks before

Risk: Cardiac complications

Stimulants (Adderall, Ritalin, Vyvanse)

Stop: 1 week before

Risk: Cardiac stress, hypertension

Cocaine, Methamphetamine

Stop: 1 week minimum

Risk: Severe cardiac complications

MDMA, Ecstasy

Stop: 1 week before

Risk: Serotonin syndrome

Tramadol

Stop: 1 week before

Risk: Seizures, serotonin syndrome

⚠️ Requires Careful Management

Benzodiazepines (Xanax, Valium, Klonopin, Ativan)

Cannot stop abruptly (seizure risk). Requires slow taper or may be continued during treatment. Work with medical team.

Opioids (Heroin, Fentanyl, Oxycodone, Morphine)

Usually continued until shortly before ibogaine to prevent early withdrawal. Timing coordinated by medical team.

Methadone, Suboxone (Buprenorphine)

Special protocols required. Extended half-life requires careful timing. Discuss with clinic.

Blood Pressure Medications

Usually continued but monitored closely. Some may require adjustment.

Parkinson's Medications (L-DOPA, Dopamine Agonists)

Usually continued but reviewed case-by-case. MAO inhibitors (Selegiline) must be stopped 2-3 weeks before.

⚑ Use Caution

Alcohol

Must complete medical detox before ibogaine due to seizure risk if dependent.

Cannabis/Marijuana

Should stop at least 3 days before. Not dangerous but may interfere with experience.

Kratom

Taper off at least 3-5 days before. Mild opioid activity.

St. John's Wort

Stop 2 weeks before - serotonergic activity.

5-HTP, L-Tryptophan

Stop 1 week before - serotonin precursors.

Next Steps

Found your medication? Discuss tapering protocols with your clinic before treatment.